1. Primary and secondary outcomes for the comparison in adults.
| Primary clinical outcomes* | Primary laboratory outcomes* | Secondary clinical outcomes* | Secondary laboratory outcomes* |
| Change in diastolic blood pressure (DBP, mmHg)c | Change in blood potassium (mmol/L)c | All‐cause mortalityi | Renal function (e.g. serum creatinine, albuminuria, urinary albumin‐to‐creatinine ratio (uACR), glomerular filtration rate (GFR))i |
| Change in systolic blood pressure (SBP, mmHg)c |
Hyperkalaemia (e.g. number of adults with serum potassium concentration > 5.5 mmol/L, or as reported by study authors)c |
Adverse events (other), excluding those that overlap with other outcomes, such as electrolyte disturbances and cardiac arrhythmias (e.g. nausea, vomiting)i | Hyponatraemia (e.g. number of adults with serum sodium concentration < 135 mmol/L, or as reported by study authors)i |
| Hypertension (e.g. number of adults with SBP > 140 mmHg or DBP > 85 mmHg, or as reported by study authors)c | Hypokalaemia (e.g. number of adults with serum potassium concentration < 3.5 mmol/L, or as reported by study authorsc | Antihypertensive medication usei | Change in fasting blood glucose (mmol/L)i |
| Blood pressure control (e.g. number of adults achieving blood pressure threshold or blood pressure under "control", or as prespecified by study authors)c | Diabetes mellitus diagnosis (as reported by study authors)i |
Change in blood triglycerides (mmol/L)i |
|
| Cardiovascular events (as reported by study authors, such as stroke, myocardial infarction, dysrhythmia)c | Change in body mass index (BMI) (kg/m2)i | Change in total blood cholesterol (mmol/L)i |
|
| Cardiovascular mortalityc | Change in 24‐hour urinary sodium excretion (mmol/24‐hours)** | ||
| Change in 24‐hour urinary potassium excretion (mmol/24‐hours)** |
Outcome ranking by WHO NUGAG ‐ Subgroup on Diet and Health: criticalc, importanti and not importantni
* Outcomes measured at longest follow‐up
** Additional outcomes added by WHO NUGAG during the guideline development process; measured using 24‐h urine samples only (spot samples excluded) Abbreviations: BMI: body mass index DBP: diastolic blood pressure GFR: glomerular filtration rate NUGAG: Nutrition Guidance Expert Advisory Group SBP: systolic blood pressure uACR: urine albumin‐to‐creatinine ratio