. Author manuscript; available in PMC: 2021 Jun 28.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2018 Nov 3;45(6):829–845. doi: 10.1007/s10928-018-9611-z

Table 1.

Parameters used in the insulin kinetics model

Parameter	Description	Unit	Value	Source
$V_{{C S}_{N}}^{I}$	Normalized volume of distribution of insulin in circulatory system	dL/kg_BW^a	0.5	[1, 29]
$V_{{S M}_{N}}^{I}$	Normalized volume of distribution of insulin in skeletal muscle	dL/kg_BW^a	1.2	[1, 29, 30]
$V_{{S M}_{N}}^{tiss}$	Normalized volume of tissue in skeletal muscle domain	mL/kg_BW^a	540	[18]
$r_{{C S}_{N}}^{I}$	Normalized clearance rate of insulin in circulatory system	1/min	0.32	[31–33]^b
$r_{{S M}_{N}}^{I}$	Normalized clearance rate of insulin in skeletal muscle	1/min	0.02	[31–33]^b
Q_{a_rest}	Tissue perfusion rate in absorbing (SC) tissue at rest	mL_b/mL_tiss/min	0.028	[18]
Q_{d_rest}	Tissue perfusion rate in delivering (SM) tissue at rest	mL_b/mL_tiss/min	0.038	[18]
h	Hematocrit percentage in blood	1	0.4	[29]
λ_a	Slope relating Q in absorbing (SC) tissue to exercise	mL_b/mL_tiss/min	0.071	[5, 50–52]
λ_d	Slope relating Q in delivering (SM) tissue to exercise	mL_b/mL_tiss/min	1.1	[19]
$P S_{a_{r e s t}}^{I}$	Permeability surface area to insulin in absorbing (SC) capillaries	mL_b/mL_tiss/min	0.005	^c
$P S_{d_{r e s t}}^{I}$	Permeability surface area to insulin in delivering (SM) capillaries	mL_b/mL_tiss/min	0.005	[27, 28]
R_a	Capillary recruitment factor in absorbing (SC) tissue	1	0.40	[46, 47]^d
R_d	Capillary recruitment factor in delivering (SM) tissue	1	1.46	[24, 26, 49]^d
γ	Saturation coefficient for PS^I	1	10	[24, 26, 49]^d

Superscripts and subscripts indicate the context of the parameter. I indicates an insulin-specific parameter. tiss indicates volume of tissue. Subscript CS or SM indicate the domain. Subscript a or d indicate ‘absorbing’ capillaries of the CS domain or ‘delivering’ capillaries of the SM domain. Subscript N indicates a normalized parameter

Multiplied by BW prior to being used in model. See demographics for BW

Derived from total clearance rate

Assumed to be the same as $P S_{d_{r e s t}}^{I}$

Derived by curve fitting to MBV literature data in SC and SM tissues