Figure 1.
Potential receptor mechanisms underlying CBD’s action against drug reward and addiction. The results from in vitro receptor binding and functional intracellular signalling assays and in vivo behavioral studies with pharmacological and transgenic approaches suggest that CBD may act as a CB1R negative allosteric modulator, a CB2R partial agonist or antagonist/inverse agonist, and a TRPV1 and 5-HT1A receptor agonist. Multiple receptor mechanisms together produce protective and therapeutic effects against drug abuse and addiction.