Table 2.
Effects of CB2 agonists on drug-taking and drug-seeking behavior in experimental animals
| Drug and dosage | Species | Results | References |
|---|---|---|---|
| JWH133 | |||
| IP 10, 20 mg/kg | Mouse | ↓ Cocaine self-administered in WT, CB1-KO, not in CB2-KO | [82] |
| ↓ PR responding for cocaine in mice | |||
| ↓ DA release in the NAc | |||
| IP 10, 20 mg/kg | Rat | No effect on FR cocaine self-administration | [87] |
| ↑ PR responding for cocaine | |||
| IP 10, 20 mg/kg | Mouse | ↓ Cocaine self-administration | [87] |
| ↓ PR responding for cocaine | |||
| IP 3, 10 mg/kg | Rat | ↓ Acquisition of cocaine CPP | [86] |
| ↓ Expression of cocaine CPP | |||
| ↓ Cocaine-induced hyperlocomotion | |||
| IP 3 mg/kg | Mouse | ↓ Expression of cocaine CPP | [159] |
| ↓ Nicotine CPP | |||
| IP 10, 20 mg/kg | Mouse | ↓ Sucrose self-administration in WT and CB1-KO, not in CB2-KO | [257] |
| 1–100 μM, local | Mouse | ↓ VTA DA neuronal firing | [82, 158] |
| GW405833 | |||
| IP 3, 10 mg/kg | Mouse | ↓ Cocaine self-administration in mice | [82] |
| O-1966 | |||
| IP 1–20 mg/kg | Mouse | ↑ Nicotine CPP at low doses | [150] |
| IP 20 mg/kg | ↓ Cocaine CPP | ||
| AM1241 | |||
| IP 1, 3, 10 mg/kg | Rat | No effect on nicotine self-administration | [89] |
| No effect on drug-induced reinstatement of nicotine seeking | |||
| No effect on cue-induced reinstatement of nicotine seeking | |||
| IP 1, 3 mg/kg | Mouse | ↓ Morphine tolerance and withdrawal | [164] |
| Xie2–64 | |||
| IP 10, 20 mg/kg | Mouse | ↓ Cocaine self-administration in WT, not in CB2-KO | [169] |
| ↓ Cocaine-enhanced optical ICSS; ↓ Optical ICSS maintained by stimulation of VTA DA neurons | |||
| IP 10, 20 mg/kg | Rat | ↓ Cocaine self-administration; ↓ PR responding for cocaine;↓ DA release in the NAc | |
| AM1710 | |||
| IP 1, 3, 10 mg/kg | Mouse | ↓ Morphine physical dependence | [165] |
| JHW015 | |||
| IP 1–100 mg/kg | Mouse | ↑ Morphine analgesia | [166] |
| ↓ Morphine CPP | |||
| ↓ Morphine-induced DA release |
CB1 type 1 cannabinoid receptor, CB2 type 2 cannabinoid receptor, CPP conditioned place preference, DA dopamine, DAT dopamine transporter, DAT-cre cre-recombinase under the control of the dopamine transporter promoter, ICSS intracranial self-stimulation, IP intraperitoneally, KO knock-out, NAc nucleus accumbens, FR fixed-ratio, PR progressive-ratio, VTA ventral tegmental area, WT wild-type, ↓ and ↑ represent decrease and increase, respectively