Table 1.
Effect of (R)-CPP on the IL-1β-induced potentiation of seizure activity caused by 0.19 nmol of kainic acid injected in the rat hippocampus
| Drug | Dose (ng) | Onset (min) | No. of seizures | Time in seizures (min) |
|---|---|---|---|---|
| Control | 11.3 ± 2.0 | 15.0 ± 1.0 | 26.3 ± 1.8 | |
| IL-1β | 1.0 | 12.3 ± 2.9 | 16.0 ± 1.0 | 52.3 ± 4.9* |
| (R)-CPP | 0.1 | 8.5 ± 1.9 | 16.0 ± 2.0 | 26.8 ± 3.3 |
| IL-1β + (R)-CPP | 8.5 ± 1.9 | 16.0 ± 3.0 | 27.0 ± 5.0**,*** |
Data are the means ± SE (n = 8–26). Control (n = 26) were rats receiving heat-inactivated (hr)IL-1β (1.0 ng in 0.5 μl) 10 min before 0.19 nmol in 0.5 μl of kainic acid. Drugs were unilaterally injected in the hippocampus in 0.5 μl 10 min before kainic acid. (R)-CPP (n = 8) were rats co-injected with heat-inactivated (hr)IL-1β before kainic acid. Seizure activity was recorded in freely moving rats for 3 hr from drug injection.
*p < 0.01 versus control.
**F(1, 30) = 7.6 (n = 9);p < 0.01 by two-way ANOVA followed by Tukey’s test for unconfounded means.
***P < 0.01 versus IL-1β.