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Effect of the COX-2 inhibitor NS-398 on the increases in neocortical CBF produced by vibrissal stimulation (A) or hypercapnia (B). NS-398 was topically superfused on the exposed somatosensory cortex, and CBF was recorded by laser–Doppler flowmetry. NS-398 attenuates the increase in CBF produced by vibrissal stimulation (A) (p < 0.01; ANOVA and Tukey's test) but does not affect the response to hypercapnia (B) (p > 0.05).
