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Aneuploidy in the large neurons of the basal nucleus of Meynert. A, B, Neurons illustrated here were probed with either BACE1(A) or BACE2 (B) probes. In each case, examples of polyploid neurons were found in Alzheimer's disease but not control brains. C, A control brain probed with the BACE1 probe from chromosome 11. This field is typical of the results in the control cases in which two or fewer spots of FISH hybridization (arrows) were found. Scale bar, 10 μm.
