Fig. 1.
The appearance of the hippocampus and basal nucleus in Alzheimer's disease. A, Loss of hippocampal pyramidal cells is evident in this cresyl violet-stained field from AD case 3 when compared with control (B). A similar reduction in cell density is visible in the large neurons of the basal nucleus of Meynert (C), compared with control (D). Immunocytochemistry reveals presence of various cell cycle-related proteins, including the DNA polymerase subunit, PCNA (E), and the G2 cyclin, cyclin B (F).