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The D1-like DA receptor antagonist SCH-23390 blocked the excitatory effect of SKF-38393 and DA. All data were collected from the same spiny neuron. A, SKF-38393 (10 μm) enhanced excitability. B, SCH-23390 (20 μm) blocked the effect of SKF-38393 (10 μm). C, DA (50 μm) enhanced excitability.D, In the presence of SCH-23390 (20 μm), DA (50 μm) reduced evoked firing.
