Table 1.
Voltage dependence and kinetics of activation ofIh expressed in different cells
| V0.5 (mV) | Slope | τ (msec, @ mV)1-a | |
|---|---|---|---|
| Rat SNL neurons | −82.5 ± 2.9 (n = 17) | 9.5 ± 1.1 (n = 15) | 47.4 ± 1.9 (@ −144 mV) |
| Rat sham neurons | −91.0 ± 2.6 (n = 14)* | 9.3 ± 1.0 (n = 11) | 43.4 ± 5.4 (@ −154 mV) |
| Human HCN1 (oocytes) | −63 ± 4.5 (n = 3) | 8.9 ± 0.6 (n = 3) | 42.5 ± 9.7 (n = 4), (@ −120 mV) |
| Human HCN3 (oocytes) | −79.3 ± 1.2 (n = 3) | 8.6 ± 0.5 (n = 3) | 434 ± 50.5 (n = 3) (@ −130 mV); 378 ± 52.5 (n = 2) (@ −140 mV) |
Values shown are the mean ± SEM for the number of cells tested in parentheses.
*
p < 0.05, Student'st test; SNL versus sham neurons.
F1-a
Fast time constants for exponential fits are shown at equivalent near-maximal voltage steps.