Figure 5.
β2 N265S mice recover more quickly from etomidate-induced LORR. Mice were tested for recovery of motor coordination after administration of etomidate (5–15 mg/kg, i.v.) or propofol (30 mg/kg, i.v.). Each group of mice were repeatedly tested on the rotarod starting from the recovery of righting reflex. a–c,β2 N265S mice recovered maximal rotarod performance much more quickly than wild-type mice (WT) (genotype, F(1,38) = 63.1; p < 0.00005), and this effect was more pronounced at higher doses of etomidate (drug dose, F(2,38) = 4.52; p < 0.02). d, Both genotypes recovered at a similar rate after propofol-induced LORR (F(1,8) = 1.35; p > 0.1). n = 6–8 for all etomidate groups; n = 5 for propofol.