| Outcome | Orlistat | Sibutramine | ||||||
| No. of studies | N | Point estimate | 95% CI | No. of studies | N | Point estimate | 95% CI | |
| Weight (kg) | 7 | 1363 | ‐2.0 | (‐2.8, ‐1.3) | 8 | 845 | ‐5.1 | (‐7.0, ‐3.2) |
| percent weight loss | 4 | 1008 | ‐2.3 | (‐3.0, ‐1.7) | 3 | 426 | ‐4.0 | (‐5.5, ‐2.6) |
| % participants with weight loss >5% | 5 | 1273 | 21.4 | (15.2, 27.6) | 2 | 204 | 21.2 | (12.5, 29.8) |
| BMI (kg/m2) | 2 | 100 | ‐0.7 | (‐1.5, 0.1) | 6 | 517 | ‐1.9 | (‐2.6, ‐1.1) |
| Waist circumference (cm) | 6 | 1111 | ‐1.8 | (‐3.0, ‐0.7) | 5 | 475 | ‐4.7 | (‐7.4, ‐2.0) |
| GHb (%) | 7 | 1373 | ‐0.5 | (‐0.6, ‐0.3) | 7 | 612 | ‐0.5 | (‐1.3, 0.2) |
| Fasting glucose (mmol/l) | 8 | 1449 | ‐0.8 | (‐1.1, ‐0.5) | 5 | 434 | ‐1.4 | (‐3.7, 1.0) |
| SBP (mm Hg) | 5 | 740 | ‐3.0 | (‐6.3, 0.3) | 6 | 673 | ‐0.8 | (‐1.7, 0.0) |
| DBP (mm Hg) | 4 | 441 | ‐4.2 | (‐7.8, ‐0.6) | 4 | 480 | 1.4 | (0.1, 2.8) |
| Total cholesterol (mmol/l) | 6 | 1324 | ‐0.4 | (‐0.5, ‐0.3) | 6 | 529 | ‐0.1 | (‐0.4, 0.2) |
| LDL cholesterol (mmol/l) | 6 | 1287 | ‐0.3 | (‐0.4, ‐0.2) | 5 | 529 | ‐0.1 | (‐0.3, 0.2) |
| HDL cholesterol (mmol/l) | 5 | 994 | 0 | (‐0.1, 0.0) | 5 | 419 | 0.1 | (0.0, 0.1) |
| Triglycerides (mmol/l) | 6 | 994 | ‐0.2 | (‐0.4, ‐0.1) | 6 | 529 | ‐0.3 | (‐0.5, 0.0) |
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