Table 4.
Outcomes of patients on or not on statin during hospitalization after intracerebral hemorrhage
| Outcome | Model | On statin n/N (%) | Not on statin n/N (%) | Odds Ratioa (95% CI) | P value |
|---|---|---|---|---|---|
| At 3 months | |||||
| Good outcomeb | Entire cohort (N = 3218) | ||||
| Univariable | 164/220 (74.5) | 1474/2998 (49.2) | 3.03 (2.22–4.14) | <0.001 | |
| Adjusted for risk factorsc | 2.24 (1.49–3.36) | <0.001 | |||
| Adjusted for propensity score | 1.93 (1.36–2.72) | <0.001 | |||
| Excluding death ≤48 h (N = 3073) | |||||
| Univariable | 164/219 (74.9) | 1474/2854 (51.6) | 2.79 (2.04–3.82) | <0.001 | |
| Adjusted for risk factorsc | 2.23 (1.48–3.36) | <0.001 | |||
| Adjusted for propensity score | 1.90 (1.34–2.68) | <0.001 | |||
| Death | Entire cohort (N = 3218) | ||||
| Univariable | 12/220 (5.5) | 630/2998 (21.0) | 0.22 (0.12–0.39) | <0.001 | |
| Adjusted for risk factorsd | 0.44 (0.22–0.87) | 0.02 | |||
| Adjusted for propensity score | 0.53 (0.28–0.97) | 0.04 | |||
| Excluding death ≤48 h (N = 3073) | |||||
| Univariable | 11/219 (5.0) | 486/2854 (17.0) | 0.26 (0.14–0.48) | <0.001 | |
| Adjusted for risk factorsd | 0.43 (0.21–0.88) | 0.02 | |||
| Adjusted for propensity score | 0.54 (0.29–1.03) | 0.06 | |||
| At 1 year | |||||
| Good outcomeb | Entire cohort (N = 3218) | ||||
| Univariable | 167/220 (75.9) | 1569/2998 (52.3) | 2.89 (2.09–3.94) | <0.001 | |
| Adjusted for risk factorsc | 2.04 (1.37–3.06) | <0.001 | |||
| Adjusted for propensity score | 1.93 (1.36–2.74) | <0.001 | |||
| Excluding death ≤48 h (N = 3073) | |||||
| Univariable | 167/219 (76.3) | 1569/2854 (55.0) | 2.63 (1.91–3.62) | <0.001 | |
| Adjusted for risk factorsc | 2.05 (1.36–3.07) | <0.001 | |||
| Adjusted for propensity score | 1.90 (1.34–2.70) | <0.001 | |||
| Death | Entire cohort (N = 3218) | ||||
| Univariable | 19/220 (8.6) | 819/2998 (27.3) | 0.25 (0.16–0.41) | <0.001 | |
| Adjusted for risk factorsd | 0.49 (0.27–0.86) | 0.01 | |||
| Adjusted for propensity score | 0.55 (0.34–0.92) | 0.02 | |||
| Excluding death ≤48 h (N = 3073) | |||||
| Univariable | 18/219 (8.2) | 675/2854 (23.7) | 0.29 (0.18–0.47) | <0.001 | |
| Adjusted for risk factorsd | 0.48 (0.27–0.86) | 0.01 | |||
| Adjusted for propensity score | 0.57 (0.34–0.95) | 0.03 | |||
CI, confidence interval; mRS, modified Rankin Scale.
Odds ratios using the not on statin group as the reference.
Good outcome defined as modified Rankin Scale 0–2.
Risk factors include the following: age, gender, smoking, heavy drink, history of diabetes mellitus, dyslipidemia, cardiovascular disease, atrial fibrillation and stroke, triglyceride, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, National Institutes of Health Stroke Scale score, and Glasgow Coma Scale score on admission, hematoma volume, hematoma location, intraventricular hemorrhagic extension, NICU/ICU care, antihypertensive therapy, intravenous mannitol therapy, neurosurgical intervention, and withdraw of support during hospitalization.
Risk factors include the following: age, heavy drink, history of diabetes mellitus, dyslipidemia, atrial fibrillation and stroke, total cholesterol, triglyceride, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, National Institutes of Health Stroke Scale score, and Glasgow Coma Scale score on admission, hematoma volume, hematoma location, intraventricular hemorrhagic extension, NICU/ICU care, antihypertensive therapy, intravenous mannitol therapy, neurosurgical intervention, and withdraw of support during hospitalization.