Table 3.
Summary of the recent papers dealing with new insights in the role of ncRNAs in mediating TCDD toxicity.
| Model | Target Genes | Epigenetic Mechanism: Non-Coding RNAs | Refs. |
|---|---|---|---|
| Kunming mice embryos | IGF2 | Lower expression levels of lncRNA H19 in TCDD-treated mice between gestation days 13.5 and 15.5, associated with augmented expression of IGF2 (on days 13.5 and 15.5); Higher expression levels of lncRNA H19 on gestation day 14.5 associated with a strong reduction of IGF2 expression. |
[66] |
| MCF-7 and Jurkat cells | CYP1B1 | The expression of miRNA-27b strongly regulates the expression of CYP1B1 protein in cancerous cells and tissues. | [70] |
| WT, L-E, H/W, AhR-null mices and mouse Hepa-1 hepatoma cells | CYP17a1, CYP7a1, Thrsp, Scd1, Tgfbp1i4 | Very little effects in lowering levels of few miRNA (101a, 138, 203, 361, 498, 542-5p), but especially miRNA 122a. | [71] |
| Fetuses Thymic cells (C57BL/6 mice) | CYP1A1 | Down-regulation of miRNAs 27a, 28, 29, 182, 203, 290, 31, 101b, and 335. | [69] |