Figure 4. Correlation networks of vaccine trial-elicited humoral immune responses probe immune complex dynamics.
Correlation networks were generated for VAX003 (A), RV144 (B), HVTN204 (C), and IPCAVD001 (D). Each node (circle) represents either a biophysical feature or an effector function. Nodes are connected with an edge (line) if they are significantly correlated. The different Ab isotypes are identified by different colors as indicated. Edge thickness and color intensity of the connecting lines are directly proportional to statistical significance and edge weight, respectively (thicker and brighter network interactions represent a stronger correlation). The size of each node is directly proportional to its degree of connected-ness (ie. the number of features to which that node is connected). See also Figure S1 and Tables S1 and S2.