Table 1. Number of genes from each organism classified using PANTHER HMMs.
| Genome | No. of genes | No. of genes with PANTHER HMM hit | No. of genes with MF association | No. of genes with BP association |
|---|---|---|---|---|
| LocusLink human | 16 232 | 14 533 (89.5%) | 10 453 (64.4%) | 10 410 (64.1%) |
| LocusLink mouse | 15 020 | 13 147 (87.5%) | 10 012 (66.7%) | 9933 (66.1%) |
| LocusLink rat | 4516 | 4391 (97.2%) | 3967 (87.8%) | 3969 (87.9%) |
| FlyBase D.melanogaster | 13 654 | 9325 (68.3%) | 6253 (45.8%) | 5719 (41.9%) |
These classifications can be searched on the PANTHER website. For LocusLink, only genes associated with at least one reviewed RefSeq (accession no. beginning with ‘NP’) were considered. Genes encoding proteins that hit a PANTHER HMM can be classified to a family or subfamily, and most but not all of these are associated with meaningful molecular function (MF) or biological process (BP) classifications.