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. Author manuscript; available in PMC: 2016 Jul 5.
Published in final edited form as: Nature. 2014 Mar 19;508(7494):123–127. doi: 10.1038/nature13158

Extended Data Figure 9. Impact of maternal retinoids in ILC3s.

Extended Data Figure 9

Maternal dietary intake of vitamin A is catabolised into bioactive retinoic acid (RA). RA signals control type 3 innate lymphoid cells (ILC3) in the embryo. Foetal ILC3s include ILC4neg and LTi4 cells. LTi4 cells are Id2+RORγt+, while enteric ILC4neg cells contain a minor subset of Id2+RORγt− cells (pre-ILCs). RA signalling operates in a cell-autonomous fashion, via direct regulation of Rorgt, programming innate pro-inflammatory cytokines and chemokines and differentiation of LTi4 cells.

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