Figure 6. Characterization of donor-characteristic cecal microbiota associated with TMAO and in vivo thrombosis potential in recipients following microbial transplantation.
Intestinal microbial community composition was assessed by (A) Principle coordinates analysis for donor and recipient mouse strains on the indicated diets. (B) Linear Discriminant Analysis (LDA) Effect Size (LEfSe) analyses were performed to identify taxa most characteristic (increased abundance) in NZW/LacJ and C57BL/6J donors. (C) Illustration of three taxa identified in recipient cecal microbes whose proportions are significantly associated with both plasma TMAO levels and occlusion time when grouped by dietary treatment (blue squares, recipients of NZW/LacJ donor cecal microbes; red circles, recipients of C57BL/6J microbes). Values in both x and y directions are plotted as mean±SE. Significance was determined using unpaired Student’s t test. See also Figure S7 and Table S5.