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. 2016 Apr 6;11(4):e0152208. doi: 10.1371/journal.pone.0152208

Table 4. Hospitalized Illness Severity Indicators Among Infant Hospitalizations for Unspecified Bronchiolitis in KID, 1997−2012.

Mechanical Ventilation Use(% hospitalizations) Inpatient Mortality*(% hospitalizations) Length of Stay, da,d Total Charges, USDa,b
1997 2012 ptrend 1997 2012 ptrend 1997 2012 ptrend 1997 2012 ptrend
Groups at High-risk for RSV
Higher-risk CHD 5.8 17.4 <0.01 0.5 1.4 0.17 3.31 4.88 <0.01 10,197.25 33,478.07 <0.01
Lower-risk CHD 3.0 14.1 <0.01 0.8 0.3 0.65 3.18 4.48 <0.01 9008.58 27,248.36 <0.01
CLD 7.7 15.5 <0.01 0.4 0.6 0.40 4.25 4.76 0.10 11,828.65 28,470.17 <0.01
Down syndrome without CHD 0.8 5.3 <0.01 0 0.5 0.24 3.47 3.07 0.69 10,014.61 16,944.97 <0.01
Congenital airway anomalies 4.8 14.5 <0.01 0 0.5 0.32 3.88 4.02 0.34 11,132.18 25,872.59 <0.01
Other high-risk conditionc 6.3 13.8 0.01 1.1 0.3 0.53 4.34 3.92 0.54 10,585.86 27,117.94 <0.01
Overall 5.4 13.5 <0.01 0.4 0.7 0.39 3.67 4.11 <0.01 10,376.88 25,962.23 <0.01
Non−high-risk 0.7 2.4 <0.01 0.02 0.01 0.83 2.28 1.96 <0.01 5432.05 10,289.26 <0.01

CHD, congenital heart disease; CLD, chronic lung disease; KID, Kids’ Inpatient Database; RSV, respiratory syncytial virus

UB, unspecified bronchiolitis.

a Geometric mean.

b Adjusted to 2015 USD.

c Other high risks: cystic fibrosis with pulmonary manifestations, neuromuscular disease, HIV, immunodeficiency, and congenital and metabolic conditions.

d A value of 0.01 was assigned to zero values in order to perform log-transformation.

* Small sample size.

If ICD-9 codes for higher-risk CHD and lower-risk CHD were both associated with a hospitalization, the hospitalization was recorded as higher-risk CHD. Down syndrome without CHD is mutually exclusive of higher-risk CHD and lower-risk CHD. Furthermore, the other high-risk group is mutually exclusive of higher-risk CHD, lower-risk CHD, CLD, Down syndrome without CHD, and congenital airway anomalies.

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