Figure 1.
Sequence Alignment of Death Domains
Listed are death domains of D. melanogaster Pelle (sp|Q05652), C. elegans Pelle (gi|2814202), human IRAK (sp|P51617), IRAK-2 (gi|4504719), human D. melanogaster Tube (sp|P22812), D. virilis Tube (sp|Q08171), Bombyx mori Tube cDNA clone e40070 (gi|4156307), human MyD88 (gi|176309), rat P75 neurotrophin receptor (sp|P07174), human Fas (sp|P25445), mouse FADD (sp|Q61160), human TNF receptor 1 (sp|P19438), and human TRADD (sp|Q15628). Red cylinders indicate D. melanogaster Pelle death domain helices; blue cylinders indicate the two Tube death domain helix inserts. The helices of D. melanogaster Tube death domain, rat P75 receptor, human Fas, and mouse FADD are underlined. Highly conserved residues are highlighted in yellow, and conserved residues are highlighted in green. Residues are colored red, orange, or green where mutations cause complete loss, partial loss, or no obvious loss of function, respectively. The D. melanogaster Pelle or Tube residues at both P:T interfaces (see text) are indicated by red dots below the sequence; those at only one of the interfaces are indicated with orange dots.