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Cleavage analysis of 2′-modified substrate RNAs. (A) Sequence and position of 2′-deoxy and 2′-O-methyl modified substrates. (B) PhosphorImaging of cleavage reactions incubated for 1 h at 30°C and resolved on a 15% denaturing polyacrylamide gel. Substrate RNAs were radiolabeled at the 5′ terminus. The arrow indicates the 9-nt cleavage product. The fraction of cleaved material is indicated at the bottom of the gel.
