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Specificity of target RNA cleavage. (A) Sequences of modified substrate RNAs. (B) PhosphorImaging of 1 h at 30°C cleavage reactions resolved on a 15% denaturing polyacrylamide gel. Substrate RNAs were radiolabeled at the 5′ terminus. The arrow indicates the 9-nt cleavage product, and the arrow with the dotted line indicates miscleavage guided by substrate S4 that contains a bulge over the cleavage site. The fraction of cleaved material is indicated at the bottom of the gel.
