Table 2.
Fasting plasma characteristics in LETO and OLETF rats chronically treated without and with L‐NAME.
| Variable | LETO CONTROL | LETO + L‐NAME | OLETF CONTROL | OLETF + L‐NAME |
|---|---|---|---|---|
| Total cholesterol, mg/dL | 77.0 ± 2.1 | 80.1 ± 2.0 | 101.0 ± 3.3* | 107.3 ± 3.4* |
| LDL, mg/dL | 41.9 ± 1.4 | 41.3 ± 2.0 | 40.0 ± 1.9 | 40.4 ± 2.5 |
| HDL, mg/dL | 27.1 ± 0.6 | 28.2 ± 0.5 | 32.4 ± 0.7* | 34.4 ± 0.7** |
| Triglycerides, mg/dL | 40.1 ± 2.4 | 52.9 ± 2.6 | 142.8 ± 10.0* | 162.5 ± 9.0* |
| NEFA, mmol/L | 0.31 ± 0.03 | 0.32 ± 0.04 | 0.61 ± 0.04* | 0.61 ± 0.03* |
| Insulin, ng/mL | 8.1 ± 1.2 | 10.1 ± 1.6 | 32.0 ± 3.8* | 22.4 ± 3.1** |
| Glucose, mg/dL | 186.0 ± 13.7 | 178.1 ± 5.7 | 309.8 ± 23.5* | 312.1 ± 19.7* |
| HOMA‐IR index | 3.9 ± 0.8 | 4.6 ± 0.8 | 25.2 ± 4.1* | 16.9 ± 2.3** |
| Leptin, ng/mL | 5.3 ± 0.9 | 4.9 ± 0.8 | 191.9 ± 59.9* | 205.1 ± 54.7* |
| MCP‐1, pg/mL | 282.8 ± 57.6 | 322.6 ± 45.8 | 209.1 ± 26.8 | 167.3 ± 8.9* |
| TNF‐α, pg/mL | 5.5 ± 0.5 | 6.0 ± 0.3 | 6.8 ± 0.8 | 5.6 ± 0.2 |
| IL‐6, pg/mL | 147.0 ± 39.4 | 196.1 ± 33.5 | 190.9 ± 58.4 | 174.3 ± 37.0 |
Values are expressed as means ± SE. LDL, low‐density lipoprotein; HDL, high‐density lipoprotein; NEFA, nonesterified fatty acids; HOMA‐IR, homeostasis model assessment of insulin resistance; MCP‐1, monocyte chemotactic protein‐1; TNF‐α, tumor necrosis factor alpha; IL‐6, interleukin 6.
*
Difference (P < 0.05) from LETO rats.
*
Difference (P < 0.05) from control rats.