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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: Nutr Rev. 2011 Jun;69(6):10.1111/j.1753-4887.2011.00394.x. doi: 10.1111/j.1753-4887.2011.00394.x

Fig. 2. Bioactive phytochemicals suppress PRR-mediated inflammation, leading to decreased risks of development and progression of chronic diseases.

Fig. 2

Both pathogen associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) from endogenous molecules from tissue injury and degradation can activate PRRs to culminate in innate immune responses, leading to host defense against invading pathogens, and promote tissue remodeling and wound healing. Dysregulated septic or sterile inflammation may increase the risks of chronic diseases. Bioactive phytochemicals may be beneficial in treating or preventing these chronic diseases through suppression of PRR activation.

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