Fig 4B.
Fasting serum triglycerides (mg/dL) predicted from age-dependent individual-specific trajectories for young-onset CR and CON monkeys. There were significant changes in triglycerides over time [F(14,843) = 17.59, p < 0.0001] and males and females were significantly different in the trends over time [F(14,843) = 5.36, p < 0.0001]. Furthermore, there was a Diet-by-Sex interaction indicating that the overall effect of CR on triglycerides was significantly different for male and female monkeys [F(1,68) = 5.07, p = 0.0276]. Specifically, CR males had lower triglycerides than CON males. By contrast, CR females had higher triglyceride levels than CON females. Overall triglyceride trajectories were based 973 observations for 81 monkeys (266 observations for 23 CON-F; 280 for 20 CON-M; 213 for 20 CR-F; 14 for 19 CR-M). For ages < 10 years, there were: 32 observations for 9 CON-F; 30 for 8 CR-F; data for males < 10 years was not available. For ages 10–15 years, there were: 76 observations for 18 CON-F; 77 for 20 CON-M; 71 for 16 CRF; 58 for 16 CR-M. For ages 15–20 years, there were: 91 observations for 20 CON-F; 95 for 19 CON-M; 72 for 16 CR-F; 75 observations for 15 CR-M. For ages 20–25 years, there were: 55 observations for 17 CON-F; 86 for 18 CON-M; 30 for 12 CR-F; 65 for 15 CR-M. For ages > 25 years, there were: 12 observations for 5 CON-F; 22 for 12 CON-M; 10 for 2 CR-F; 16 for 11 CR-M.