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Maximum relaxation responses to Ach (10 µM) in the carotid artery contracted by PE (10 µM) observed 20 h after irradiation. (A) Effect of L-NA (100 µM), ODQ (10 µM), AG (100 µM), and TEA (1 mM) on non-irradiated arterial rings. L-NA and ODQ similarly decreased maximum relaxation responses. Effects of the drugs on arterial rings irradiated by (B) the in vivo method and (C) the ex vivo method.
