Table 1. Summary of Cannabinoid Effects In Vitro.
| Gamma (30–80 Hz) | Beta (13–29 Hz) | Alpha (8–12 Hz) | Theta (4–7 Hz) | |
|---|---|---|---|---|
| (a) Medial Prefrontal Cortex (mPFC) | ||||
| Chronic adolescent WIN treatment | P<0.001 | P<0.001 | P<0.001 | P=0.071 |
| Vehicle (n=12 slices per 8 mice) vs WIN (0.25 mg/kg) (n=16 slices per 10 mice) | P=0.018, 52% | P=0.001, 46% | P=0.028, 51% | |
| Vehicle vs WIN (1 mg/kg) (n=14 slices/10 mice) | P<0.001, 26% | P<0.001, 17% | P<0.001, 35% | |
| Chronic adult WIN treatment | ||||
| Vehicle (n=8 slices per 3 mice) vs WIN (1 mg/kg) (n=12 slices per 5 mice) | P=0.543 | P=0.918 | P=0.662 | P=0.264 |
| Chronic adolescent THC treatment | ||||
| Vehicle (n=12 slices per 8 mice) vs THC (5 mg/kg) (n=21 slices per 8 mice) | P<0.001, 35% | P<0.001, 14% | P<0.001, 18% | P<0.001, 24% |
| (b) Primary Somatosensory Cortex (SCx) | ||||
| Chronic adolescent WIN treatment | P=0.002 | P<0.001 | P<0.001 | P=0.006 |
| Vehicle (n=21 slices per 12 mice) vs WIN (0.25 mg/kg) (n=26 slices per 12 mice) | P=0.051 | P=0.028, 72% | P=0.066 | P=0.103 |
| Vehicle vs WIN (1 mg/kg) (n=24 slices per 12 mice) | P<0.001, 37% | P<0.001, 49% | P<0.001, 33% | P<0.001, 49% |
| Chronic adult WIN treatment | ||||
| Vehicle (n=8 slices per 3 mice) vs WIN (1 mg/kg) (n=13 slices per 5 mice) | P=0.523 | P=0.305 | P=0.294 | P=0.225 |
| Chronic adolescent THC treatment | ||||
| Vehicle (n=21 slices per 12 mice) vs THC (5 mg/kg) (n=24 slices per 12 mice) | P=0.131 | P=0.901 | P=0.129 | P=0.025, 75% |
(a) Summary of statistical analyses of cannabinoid effects on the power of pharmacologically evoked LFP oscillations recorded in vitro in mPFC. Kruskal–Wallis (KW) tests determined significant differences among three treatment conditions, and pairwise comparisons were tested with Mann–Whitney U-tests (MWU; significant P<0.05). No pairwise comparisons were performed if KW P>0.05. MWU tests compared two treatment conditions. Percentages reported are relative to median LFP power recorded in vehicle-treated mice. (b) Summary of statistical analysis of LFP oscillations recorded in vitro in SCx. Analysis was performed as in (a)