Figure 3.
Chronic adolescent THC administration suppresses oscillations in vitro in mouse mPFC but not SCx. (a) THC (5 mg/kg) or vehicle was administered to adolescent mice (P35–P55) and LFPs were recorded in slices from adult mice (>P100). (b–e) Box and whisker plots of power from FFTs of LFPs in mPFC of adult mice with KA+CCh perfusion. Power from adolescent THC or vehicle-treated mice were compared using MWU tests (significant P<0.05). (f–i) Box and whisker plots of power extracted from FFTs of LFPs in SCx of adult mice in the presence of KA+CCh. Mice were treated and statistics were performed as in (b–e).