Fig. 3. Antibiotic-induced changes in colonic flora have profound influence on the TCR repertoire of colonic tTregs.
a, The effect of antibiotic treatment on the proportion of Tregs in indicated organs. Three mice per group were analyzed. b, Fifty dominant TCRs (Table S4) of colonic Tregs from untreated (red bars) or antibiotic-treated (black bars) mice and their frequencies in analyzed repertoires. TCRs not found on CD4+Foxp3+ thymocytes are star-marked. c, Diversity index (Renyi Entropy Function) of Tregs from indicated organs of untreated and antibiotic-treated mice. REF close to “0” corresponds to diversity of low abundant TCRs and close to “2” for high abundant TCRs. d, MII indices for TCR repertoires of CD4+Foxp3− and Treg populations from antibiotic-treated mice.