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Protein synthesis is required for DHPG-induced I-LTD in the VTA. The protein synthesis inhibitor anisomycin (30 μM, n=8, p<0.05 vs control) or cycloheximide (80 μM, n=6, p<0.05 vs control) blocked DHPG-induced I-LTD but did not significantly affect the early component of DHPG-induced depression of IPSCs (p<0.05 vs control). Error bars indicate SEM.
