Table 1. Physical and biochemical parameters of experimental animals.
| Parameters | week | db/m control | db/db + vehicle | db/db + celastrol |
| Body weight (g) | 0 | 24.28±0.18 | 33.2±0.41*** | 33.4±0.81*** |
| 4 | 29.14±0.40 | 45.7±1.29*** | 38.0±1.26***,‡ | |
| 8 | 29.00±0.53 | 46.5±1.94*** | 37.2±2.22***,† | |
| Daily Food intake (g) | 0 | 3.53±0.31 | 4.68±0.26 | 4.95±0.53 |
| 4 | 3.14±0.09 | 4.93±0.08*** | 3.85±0.24**,‡ | |
| 8 | 2.97±0.17 | 5.06±0.18*** | 4.10±0.46**,† | |
| Daily water intake (g) | 0 | 5.35±0.25 | 7.87±0.22*** | 7.45±0.69** |
| 4 | 3.98±0.22 | 16.45±0.47*** | 4.45±0.43***,‡ | |
| 8 | 3.60±0.16 | 17.56±0.54*** | 8.14±0.62**,‡ | |
| Fasting plasma glucose (mmol/l) | 0 | 9.3±0.5 | 18.2±1.9** | 19.4±3.4** |
| 4 | 8.3±0.3 | 35.7±1.8*** | 17.2±4.2*,‡ | |
| 8 | 8.59±0.32 | 32.1±1.8*** | 16.2±3.1*,‡ | |
| UV (ml/day) | 0 | 0.45±0.08 | 0.66±0.10 | 0.71±0.11 |
| 4 | 0.39±0.08 | 0.75±0.12* | 0.68±0.03* | |
| 8 | 0.39±0.05 | 1.42±0.32** | 0.76±0.14 | |
| Kidney/100 g BW | 8 | 0.49±0.02 | 1.36±0.05*** | 0.52±0.03‡ |
| Heart/100 g BW | 8 | 0.36±0.02 | 0.38±0.02 | 0.35±0.02 |
| Fat/100 g BW | 8 | 1.15±0.08 | 6.08±0.41*** | 2.73±0.74*,‡ |
| Liver/100 g BW | 8 | 4.17±0.63 | 7.26±0.56** | 7.58±1.13** |
| P-adiponectin ( µg/ml) | 8 | 2.89±0.20 | 2.51±0.05 | 29.1±2.44**,‡ |
| P- 8-isoprostane(pg/ml) | 8 | 249±29.8 | 473±74.4 | 814±172 |
| P-creatinine ( µmol/l) | 8 | 35.0±4.0 | 45.0±6.0 | 29.0±2.0† |
| P-insulin (ng/ml) | 8 | 1.71±0.38 | 9.73±0.81*** | 8.80±2.41** |
| SBP (mmHg) | 8 | 118±16 | 115±15 | 124±11 |
UV, urine volume; P, plasma. Values are expressed as means ± SEM. Statistical analysis was performed between groups at the same time periods; *P<0.05; **P<0.01; ***P<0.001 vs. db/m control; †P<0.05; ‡P<0.01 vs. db/db + vehicle.