Figure 6. Enhancer H3K27ac oscillation temporally correlates with transcript oscillation from proximal gene or cluster of genes.
Transcript (red/green) and H3K27ac (blue/light blue) read density is are illustrated at (A) Cry1 and (B) Insig2 loci at eight time points (rowsH3K4me3 and H3K4me1 read density is given as a reference in the bottom panel and H3K4me3 is shown as insets at each time points (black). Enhancers are indicated as blue bars and arrows indicate promoters of target genes. (C and D) Single enhancers drive transcription of multiple proximal genes. Gene models, peak phase of oscillating transcripts are shown on top. Blue horizontal bars denote enhancer regions marked by oscillating H3K27ac and absence of H3K4me3.