Figure 5. CD103+ DCs upregulate IL-17 promoting genes.
(a) The top 200 genes based on P value for the contrast between CD103+CD11c DCs and CD103-CD11c+ DCs from MLNs of SIV-uninfected RM. The complete linkage method was used for hierarchical cluster analysis. Both rows and columns are clustered. Each row represents normalized expression value for a single gene, and each column represents a sample (data are from MLS of 3 SIV-uninfected animals and CD103+CD11cā DCs are left and CD103-CD11c+ DCs are right). (b) Fold change of selected genes that were upregulated in CD103+ DCs (top) or CD103-CD11c+ DCs (bottom). P values donated above each gene fold change. (c) The network from IPA analysis for selected genes is shown. Color: red indicates up-regulation (fold change >= 1.5); green indicates down-regulation (fold change <= ā1.5); grey indicates the genes whose expression values are between ā1.5 and 1.5. Shape: triangle represents kinase; square represents cytokine; rectangle represents ligand-dependent nuclear receptor; diamond represents enzyme; trapezoid represents transporter; ellipse represents transcription regulator; circle represents others.