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Novel approaches to osteoporosis treatment.
| Compound | Osteoblast | Adipocyte | Osteoclast |
|---|---|---|---|
| Cathepsin | ↓ differentiation | ||
| K inhibitor | ↓ activity | ||
| ↑ apoptosis | |||
| SOST antibody | ↑ activity | ||
| Interferon γ | ↑ activity | ↓ differentiation | ↑ activity (uncoupling favoring formation) |
| ↑ differentiation | |||
| BMP agonists | ↑ activity | ||
| ↑ differentiation |
BMP, bone morphogenetic protein; SOST, sclerostin.
