Figure 5.
Antisense (AS) to NaN/SNS2 administered to rats with SNL injury produced no effect on either tactile allodynia (A) or thermal hyperalgesia (B). Groups of six rats were used for each of the ODN or saline treatments and were monitored daily for tactile (von Frey) and thermal nociceptive (radiant heat) responses of the ipsilateral hindpaw. Mismatch (MM) or AS ODN (45 μg, intrathecal) were given twice daily to sham-operated rats and rats with SNL injury. Neither MM nor AS reversed tactile allodynia or thermal hyperalgesia in the ligated groups, and, likewise, neither treatment altered baseline values in the sham-operated groups. (●), sham-operated, AS; (■), SNL, AS; (▵), sham-operated, MM; (♦), SNL, MM.