Figure 3. RNAi suppression of dormancy upregulated genes accelerates tumor take and growth of ER+ luminal MCF-7 cells.
(A) Percent of tumor take at the indicated time points after injecting with 4 106 MCF7 cells treated with the indicated siRNAs in the mouse mammary fat pad. (B) Tumor volume (mm3) at 12 days for tumors generated by MCF7 cells treated with the indicated siRNAs and injected in the mouse mammary fat pad. (C–D) Q-PCR analysis for the expression of BHLHE41 (C) and NR2F1 (D) mRNAs after 48 hrs of treatment with control or specific siRNAs targeting these mRNAs.