Table 4.
Hazard Ratio of 33 month mortality according to quartiles of Endotoxin in 306 maintenance hemodialysis patients.
| Endotoxin Quartiles | Q1 (n=77) HR(%CI) (0.26–0.90) |
Q2 (n=76) HR(%CI) (0.91–1.26) |
Q3 (n=76) HR(%CI) (1.28–2.23) |
Q4 (n=77) HR(%CI) (>=2.24) |
|---|---|---|---|---|
| Unadjusted | 0.97 (0.49–1.92) P=0.09 |
1(Reference) | 1.40 (0.75–2.7) P=0.28 |
0.89 (0.45–1.75) P=0.73 |
| Case-mix* | 1.16 (0.58–2.3) P=0.67 |
1(Reference) | 1.60 (0.58–2.3) P=0.2 |
0.88 (0.44–1.76) P=0.73 |
| Previous + MICS# | 1.07 (0.51–2.22) P=0.85 |
1(Reference) | 1.64 (0.84–3.2) P=0.14 |
0.82 (0.40–1.69) P=0.60 |
| Previous + inflammation†(full mode) | 1.07 (0.50–2.28) P=0.86 |
1(Reference) |
1.83 (0.93–3.6) P=0.08 |
0.84 (0.40–1.75) P=0.64 |
Abbreviation: CI, confidence interval; HR, Hazard Ratio; MICs, Malnutrition-inflammation-cachexia syndrome.
*
Case-Mix variables includes age, sex, race/ethnicity, diabetes, and log vintage
#
MICS variables includes values for albumin, creatinine, hemoglobin, total iron-binding capacity, normalized protein catabolic rate, and body mass index.
†
Full Model consists of case mix and MICS and logarithm of 3 inflammatory markers: C-reactive protein, interleukin 6, and tumor necrosis factor-α