Table 5.
Summary of pdk-1 loss-of-function phenotypes
|
Genotype
|
Daf-c
|
Egl
|
Lon
|
Cpy
|
Brood size at 20°Ca
|
|---|---|---|---|---|---|
| Wild type | + | + | + | + | 291 ± 69 (5) |
| pdk-1(sa709) | +/−b | +/−b | − | +/−b | N.D.c |
| pdk-1(sa680) | − | − | − | − | 24 ± 20 (4) |
| osm-6(p811); pdk-1(sa680) | − | − | − | − | 38 ± 17 (5) |
| daf-5(e1385); pdk-1(sa680) | − | − | − | − | 36 ± 23 (5) |
| pdk-1(sa680) daf-12(m20) | + | − | − | − | 17 ± 16 (5) |
| daf-16(m27); pdk-1(sa680) | + | + | + | + | 230 ± 43 (5) |
| akt-1(mg144); pdk-1(sa680) | +/−d | − | − | − | 135 ± 61 (3) |
a
Mean brood size ± s.d. with the number of animals assayed in parantheses.
b
Indicates that pdk-1(sa709) has defective phenotypes that are weaker than those of pdk-1(sa680).
c
Not determined. However, casual observation suggests that pdk-1(sa709) does not have an obvious fertility defect.
d
Partial suppression of the Daf-c phenotype.