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DCs from GF animals are defective in inducing Th17 and Th1 responses from CD4+ T cells. Purified CD4+ T cells from MOG-Tg mice were cultured with MLN DCs from SPF or GF mice in the absence or presence of MOG peptide and IL-2. At day 3 and day 5 of culture, IL-17A (A) and IFNγ (B) cytokines were measured by ELISA. Data are representative of two independent experiments, with mean ± SD of samples run in triplicate. *P < 0.05; **P < 0.005.
