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(A) An example of feedforward transcriptional regulatory circuitry in human ES cells. Regulators are represented by blue circles; gene promoters are represented by red rectangles. Binding of a regulator to a promoter is indicated by a solid arrow. Genes encoding regulators are linked to their respective regulators by dashed arrows.
(B) The interconnected autoregulatory loop formed by OCT4, SOX2, and NANOG.
