Figure 3. Erasure of DNA methylation in different classes of transposable elements in PGCs.
Methylation levels of different classes of transposons in ES cells, Np95-/- ES cells, and various tissues of C57BL/6J and Aid-/- knockout mice are shown based on ratios of methylated to unmethylated BS-Seq reads. Placenta, fetal carcass and PGCs were all collected at E13.5. Note that LTR-ERV1 and LTR-ERVK elements retain more methylation in PGCs than any other repeat family.