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Eszopiclone (ESZ) administered intravenously (i.v.) significantly decreased acetylcholine (ACh) release in the pontine reticular formation. A. Eszopiclone (3 mg/kg) administered to isoflurane-anesthetized rats (n = 3) caused a 50.2% decrease in ACh release. B. Eszopiclone (3 mg/kg) administered to intact, freely moving rats (n = 3) caused a 52.7% decrease in ACh release.
