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. Author manuscript; available in PMC: 2011 Jul 2.
Published in final edited form as: J Mol Biol. 2010 May 4;400(1):96–107. doi: 10.1016/j.jmb.2010.04.060

Figure 5. Sharkey is compatible with alternative ZFN architectures.

Figure 5

Mutagenesis efficiencies for asymmetric ZFN scaffolds comprised of wild-type FokI cleavage domain (black) or Sharkey mutations (white). (a) RR::DD, RR::DS and (b) KK::EL FCD architectures were fused to E4 or P3.ZFPs. Stimulated mutagenesis was measured by the counting % of EGFP positive cells. Error bars indicate standard deviation of three replicates.

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