TABLE 3.
Longitudinal relationship* of C-reactive protein (CRP) and interleukin-6 (IL-6) levels at baseline (1991-1993) with cognitive symptoms of depression at follow-up (2003-2004).
| Depressive symptoms at follow-up † | |||||
|---|---|---|---|---|---|
| Inflammatory markers at baseline | n | β | (SE) | p-value | p-value for sex interaction |
| CRP | |||||
| Men and Women | 3339 | 0.046 | (0.016) | 0.004 | 0.319 |
| Men | 2388 | 0.058 | (0.019) | 0.002 | |
| Women | 951 | 0.020 | (0.030) | 0.522 | |
| IL-6 | |||||
| Men and Women | 3298 | 0.046 | (0.016) | 0.005 | 0.610 |
| Men | 2347 | 0.054 | (0.020) | 0.006 | |
| Women | 951 | 0.032 | (0.028) | 0.259 | |
*
Adjusted for age, sex and ethnicity.
†
Additional adjustment for cognitive symptoms of depression at baseline. β = linear regression standardized coefficients expressing the change in standardized cognitive symptoms of depression per one standard deviation in the levels of the inflammatory markers.