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Effect of in-vitro CRP treatment on vascular reactivity. a) Dilation of mesenteric arterioles isolated from control rats to acetylcholine was examined before and after incubation with NOS inhibitor L-NAME (10 μM) for 30 min or with CRP (7 μg/ml) or boiled CRP (7 μg/ml) for 60 min. b) Dilation of mesenteric arterioles to sodium nitroprusside was examined before and after incubation with L-NAME (10 μM) or CRP (7 μg/ml). n = number of vessels/1 per rat. *P<0.05 L-NAME or CRP vs. Control.
