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Beta-amyloid (Aβ) production and clearance. Amyloid precursor protein (APP) undergoes proteolytic cleavage by alpha- and gamma-secretase to yield a 40 amino acid fragment (Aβ40) or 42 amino acid fragment (Aβ42). Possible fates include parenchymal or vascular deposition as amyloid, proteolytic cleavage, perivascular drainage or efflux across the blood-brain barrier. CAA, cerebral amyloid angiopathy.
