Fig. 1.
Ligand activation of PPARβ/δ inhibits cell proliferation of HaCaT keratinocytes. HaCaT cells were treated with either GW0742 (A and C) or GW501516 (B and D) with the indicated concentration of ligand (arrow) in the presence (A and B) or absence (C and D) of culture medium with serum and cell number was quantified as described under Materials and Methods. Values represent the mean ± S.E.M. *, significantly different values (P < 0.05) from vehicle (DMSO) at the particular time point, as determined by ANOVA and Bonferroni’s multiple comparison test.