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Ang2 inhibition blocks arteriogenesis and the formation of collaterals. Mice underwent femoral artery ligation and were treated with vehicle or L1-10. A, Shown are representative whole mount confocal images from the distal region of the ischemic adductor muscle (red for PECAM-1 and green for SMA). B, Yellow representing arterioles and red representing capillaries were quantified and expressed as a percent of vehicle. (mean±SEM, n=4 to 5; *P<0.05 compared to vehicle and FC control).
