FIG. 2.
Post hoc analysis of the CEPP performance. The top-ranking 0.5% of candidate peptides derived from MHV-68 and vaccinia virus (VV), as assigned by the CEPP, are plotted (x axis) against those epitopes that were confirmed to give a CD8 T-cell response (y axis). Each confirmed epitope is treated as an individual and discrete event. The vertical line depicts the 0.5% cutoff value of the top-ranking epitopes of the MHV-68 screen. Based on the results obtained with vaccinia virus, there are significantly (P = 0.034) fewer H-2Db-restricted MHV-68 epitopes than expected for that restriction element.