Figure 5. Hypothetical scheme to explain the effect of increased extracellular EAAs on MPS.
Hypothetical scheme showing how increased extracellular EAAs (L) may modulate MPS (the last stage in the sequence L-Protein) and cause diminution in intramuscular EAAs. Stages M-O simply represent biochemical entities involved in the initiation and elongation of protein synthesis. The increased availability of the extracellular amino acids is signalled to the protein synthetic apparatus via a membrane-bound sensor labelled ‘?’, which is independent of the amino acid transporters. The sensor must transmit a signal through another unknown mechanism (X).